ECIM 2012 - 5th European Congress for Integrative Medicine - “The Future of Comprehensive Patient Care” - 21-22 September 2012 - Palazzo dei Congressi, Florence
Environmental diseases, oxidative stress and genetic polymorfism
F. Cosentino1, M.C. Giuliano2 , F. Bisicchia3
1Gastroenterology and Hepatology Department Milton Keynes General Hospital NHS – UK, Milton Keynes - 2Ph GP NHS Italy, Gravina di Catania -3Ph GP Trainee NHS Italy, Catania
The increasing industrialization and globalization have led to an increasing of volatile organic compounds (VOC an increasing of the concentration of heavy metals (lead, mercury, arsenic, cadmium) that in the past were not at concentrations not harm, and an aggravating electromagnetic pollution. All that is the cause of environmental illness. The way in which environmental disease are expressed depends on how the environmental agent enters the body, how it is metabolized, and route of excretion. L ‘increased load of xenobiotics and the consequent increase in oxidative stress would be behind the rise of allergic diseases and in many cases of neoplastic diseases. In particular, some genetic polymorphisms (CYP2D6, PON1, MnSOD, SOD3, GSTP1, GSTM1 GSTT1) or epigenetic alterations through a reduced or absent elimination of superoxide and the subsequent production of peroxynitrite and hydroxyl groups could be responsible for worsening chronic degenerative diseases such as SBS (Sick BuildingSyndrome), CFS (Crhonic Fatigue Syndrome), FMS (Fibromyalgia Syndrome) and MCS (Multi Chemical Sensitivity). Some of these diseases are often diagnosed in the same individual, would suggest that they may represent an epiphenomenon of a common denominator across the nuclear membrane lipid peroxidation damage. DNA damage (epigenetic alteration) and relative decrease of the enzymatic functions of superoxide dismutase, catalase, glutathione peroxidase and transferase justify the low threshold of sensitivity to xenobiotics. The purpose of this research is to perform a retrospective analysis of patients who have already been given the diagnosis of environmental disease, but where neurological symptoms of acute respiratory or may instead be related to somatoform disorders. All patients will undergo tests at the first level, to verify the actual presence of increased oxidative stress, possible involvement of the immune system, presence of neoplastic diseases. Confirmed the presence of increased oxidative stress, are subjected to subsequent investigations (second level) such as the dosages of these enzyme activities in leukocyte and therefore searched for genetic polymorphisms.